课程简介
Hello everyone! Welcome to advanced neurobiology! Neuroscience is a wonderful branch of science on how our brain perceives the external world, how our brain thinks, how our brain responds to the outside of the world, and how during disease or aging the neuronal connections deteriorate. We’re trying to understand the molecular, cellular nature and the circuitry arrangement of how nervous system works. Through this course, you'll have a comprehensive understanding of basic neuroanatomy, electral signal transduction, movement and several diseases in the nervous system. This advanced neurobiology course is composed of 2 parts (Advanced neurobiology I and Advanced neurobiology II, and the latter will be online later). They are related to each other on the content but separate on scoring and certification, so you can choose either or both. It’s recommended that you take them sequentially and it’s great if you’ve already acquired a basic understanding of biology. Thank you for joining us!
课程大纲
课程说明
参考资料
拓展阅读
其他
主讲教师
张研 教授
张研,北京大学生命科学学院教授,北京大学麦戈文脑研究所研究员。2003年在McGill大学获博士学位。长期从事神经退行性疾病,特别是阿尔茨海默氏症中神经元凋亡及淀粉样沉积的代谢途径的研究工作。利用人类原代神经元为模型研究神经退行性疾病,采用细胞内显微注射系统,将外源性蛋白及表达质粒引入细胞等方法分析胞内淀粉样沉积毒性及其作用通路,为淀粉样沉积导致阿尔茨默症的发病机制提供了新的见解。发现并纯化内源性半胱氨酸蛋白酶抑制因子;提出朊蛋白的细胞保护假说。在此基础上,筛选并研究了一系列可以对抗细胞内淀粉样沉积毒性的物质;发现了包含甘丙肽和吗啡在内的临床应用药物的细胞保护作用并研究了其作用机制和分子通路;发现并阐明神经细胞纳米连接的诱导机制;深入探讨了纳米连接在神经退行性疾病中的作用;发现家族型老年性痴呆的突变可以导致microRNA调节和神经元早期发育的异常;揭示了轴突起始节部位异常和老年性痴呆的病理关系;提出了在遗传性AD突变携带者中,神经元存在着早期的发育缺陷。近10年来在国际著名的神经生物学和细胞生物学期刊Neuron, PNAS, Cell Reports,Prog Neurobiol, Nat Methods, Nat Protocol, J Cell Biol, Neurosci Biobehav Rev, J Neurosci, Cell Death Differ, Cell Death Dis, JACS, J Cell Sci等发表学术论文50余篇,先后被引用1000余次,其中单篇论文最高他引次数近300次。为诸多国际期刊审稿并担任有影响力的专业期刊的编委。
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